30多年来断断续续研究了巨噬细胞(Mφ)杀伤结核杆菌(TB)的作用。最近的研究提示了Mφ依靠所产生的过氧化氢杀伤TB。Mφ溶酶体酶对TB的作用也引起了人们的注意。 1981年作者研究了小鼠腹腔Mφ在体外对鼠分枝杆菌的杀伤作用,发现正常小鼠Mφ在体外被感染后,杀伤能力很小;相反如事前保存在免疫激活脾细胞的上清液中则能在24小时内杀伤90%以上被吞噬的细菌。 For more than 30 years, the effect of macrophage (Mφ) killing Mycobacterium tuberculosis (TB) has been studied intermittently. Recent studies suggest that Mφ kills TB with hydrogen peroxide produced. Mφ lysosomal enzymes on the role of TB has also attracted people’s attention. In 1981, the author studied the murine mycobacterium Mφ mouse in vitro killing effect and found that normal mouse Mφ infection in vitro, the ability to kill small; the contrary as previously saved in immune-activated spleen cell supernatant You can kill more than 90% of the bacteria that are swallowed within 24 hours.