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目的:探讨硝普钠联合倍他乐克对主动脉夹层(AD)的疗效。方法:将28例AD患者纳入研究,随机分为治疗组和对照组各14例,记录两组患者给药后5、10、20、30min的血压、心率变化。结果:治疗后5、10、20、30min内血压,治疗组下降程度均高于对照组,两者比较,差异显著(P<0.01);治疗后5min内心率,两组比较,差异无统计学意义(P>0.05);治疗后10、20、30min,治疗组下降程度均高于对照组,两者比较,差异显著(P<0.01)。结论:硝普钠结合倍他乐克可有效控制血压和心率,综合治疗主动脉夹层效果颇佳,具有临床推广价值。
Objective: To investigate the curative effect of sodium nitroprusside and metoprolol on aortic dissection (AD). Methods: Twenty-eight patients with AD were enrolled in the study and randomly divided into treatment group and control group, with 14 cases in each group. The changes of blood pressure and heart rate were recorded at 5, 10, 20 and 30 minutes after administration. Results: After 5, 10, 20 and 30 minutes of treatment, the blood pressure and the degree of decrease in the treatment group were significantly higher than those in the control group (P <0.01). There was no significant difference in heart rate between the two groups (P> 0.05). At 10, 20 and 30 min after treatment, the decrease in the treatment group was higher than that in the control group, the difference was significant (P <0.01). Conclusion: Sodium nitroprusside combined with metoprolol can effectively control blood pressure and heart rate, the comprehensive treatment of aortic dissection is quite good, with clinical value.