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目的探讨小剂量红霉素联合多潘立酮在早产儿喂养不耐受中的疗效。方法选取清远市佛冈县人民医院新生儿重症监护室收治的胎龄37周内喂养不耐受早产儿92例。使用随机数字表分组,按照1:1:1分为小剂量红霉素联合多潘立酮(A组)、小剂量红霉素组(B组)及对照组(C组)。对比三组婴儿的喂养不耐受症状消失的时间、达到40 kcal/(kg·d)日龄、达到80 kcal/(kg·d)日龄、达全肠道喂养的日龄、恢复出生体重的日龄、肠外营养相关性胆汁淤积、败血症等。结果 A、B组在喂养不耐受症状消失的时间、达到40 kcal/(kg·d)日龄、达到80 kcal/(kg·d)日龄、达全肠道喂养的日龄、恢复出生体重的日龄明显低于C组,差异有统计学意义(P<0.05)。A组患儿达到40 kcal/(kg·d)日龄、达到80 kcal/(kg·d)日龄、达全肠道喂养的日龄、恢复出生体重的日龄低于B组,差异有统计学意义(P<0.05);A、B组在喂养不耐受症状消失的时间、肠外营养相关性胆汁淤积及败血症发病率上差异无统计学意义。A、B组治疗后肝功能均未见明显异常,A组使用多潘立酮治疗后均未出现明显的头后仰、肢体强直、肌肉震颤等锥体外系反应。结论小剂量红霉素联合多潘立酮治疗早产儿喂养不耐受效果优于小剂量红霉素,两者联用均未见明显副作用。
Objective To investigate the efficacy of low-dose erythromycin combined with domperidone in feeding intolerance in preterm infants. Methods Totally 92 preterm infants were inoculated within 37 weeks of gestational age in neonatal intensive care unit of Fogang People’s Hospital of Qingyuan City. The patients were divided into three groups according to the random number table: low dose erythromycin combined with domperidone (group A), low dose erythromycin group (group B) and control group (group C). Comparing the disappearance of feeding intolerance symptoms of three groups of infants, reaching a day of 40 kcal / (kg · d), reaching a day of 80 kcal / (kg · d), reaching the age of full gut feeding and restoring birth weight Day-old, parenteral nutrition related cholestasis, sepsis and so on. Results A, B group reached the age of 40 kcal / (kg · d) on the day of disappearance of feeding intolerance and reached the age of 80 kcal / (kg · d) The body weight of the day was significantly lower than the C group, the difference was statistically significant (P <0.05). A group of children reached 40 kcal / (kg · d) days of age, reaching 80 kcal / (kg · d) days of age, up to the total intestine feeding day age, recovery of birth weight was lower than the B group, the difference was Statistical significance (P <0.05). There was no significant difference in the time of disappearance of feeding intolerance, the incidence of parenteral nutrition-related cholestasis and sepsis in groups A and B. No significant abnormalities of liver function were observed in group A and group B. No significant head-adduction, limb rigidity, muscular tremor and other extrapyramidal reactions were observed in group A after treatment with domperidone. Conclusions Low dose erythromycin combined with domperidone is superior to low dose erythromycin in feeding intolerance in preterm infants, and there is no obvious side effect.