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目的:提高和调节细胞免疫功能及病毒复制抑制功能。方法:以大剂量精制胸腺肽联合阿昔洛韦治疗慢性乙型肝炎36例,其中男27例,女9例,平均年龄26±11岁。结果:经57±27天治疗后,CD_4~+细胞及CD_4~+/CD_8~+率明显上升,CD_8~+细胞明显下降,均优于对照组(P<0.01),HBeAg和HBV-DNA阴转率分别为61％与44％,与对照组相比有显著性差异。结论:将大剂量精制胸腺肤与阿昔洛韦联用,具有协同作用,可以提高和调节细胞免疫功能。
Objective: To improve and regulate cellular immune function and virus replication inhibitory function. Methods: 36 cases of chronic hepatitis B were treated with high dose of thymosin and acyclovir, including 27 males and 9 females, with an average age of 26 ± 11 years. Results: After 57 ± 27 days of treatment, the percentage of CD_4 ~ + cells and CD_4 ~ + / CD_8 ~ + increased obviously and the percentage of CD_8 ~ + cells decreased significantly (all P <0.01) Transfer rates were 61% and 44%, respectively, compared with the control group were significantly different. Conclusion: The high dose of purified thymus skin combined with acyclovir, synergistic effect, can improve and regulate cellular immune function.