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刚地弓形虫是一种原生动物,被其感染后引起一系列的病理变化和症状。刚地弓形虫表膜抗原SAG1是一类重要的膜蛋白,研究发现其表膜抗原SAG1在制备单克隆抗体、疫苗和临床快速诊断等方面都有着重要的作用。本文主要就弓形虫表膜抗原SAG1的分子生物学信息、SAG1在机体内的免疫应答和应用研究进行综述。
Toxoplasma gondii is a protozoa that causes a series of pathological changes and symptoms after it is infected. Toxoplasma gondii surface antigen SAG1 is a kind of important membrane protein. It is found that its surface antigen SAG1 plays an important role in the preparation of monoclonal antibodies, vaccines and rapid clinical diagnosis. In this paper, the molecular biology information of Toxoplasma gondii surface antigen SAG1 and the immune response and application of SAG1 in vivo are reviewed.