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目的:观察硬膜外腔(ES)注射吗啡(M)复合去炎松A(TA)治疗癌痛作用和TA药代动力学研究。方法:观察104例ES注射M复合TA的癌痛病人,高效液相色谱法检测8例TA血药浓度后行药代动力学研究。结果:每日注射M3.84±3.94mg;副反应率7.69%;平均视觉模拟评分(VAS)3.16±2.83分,TA平均消除半衰期(t_(1/2))1.63±0.36/d,平均累积系数(R)1.06±0.04μg/ml。结论:长期间断ES注射tA可增强M镇痛效果,未形成血中TA蓄积。
Objective: To observe the epidural (ES) injection of morphine (M) combined with triamcinolone A (TA) in the treatment of cancer pain and TA pharmacokinetics. Methods: One hundred and forty patients with cancer pain who received ES injection of compound TA were observed. The pharmacokinetics of 8 patients with TA were determined by high performance liquid chromatography. RESULTS: M3.84±3.94mg was injected daily; the side reaction rate was 7.69%; the average visual analogue scale (VAS) was 3.16±2.83 points; the average elimination half-life of TA (t_(1/2)) was 1.63±0.36/d. The coefficient (R) is 1.06±0.04 μg/ml. CONCLUSIONS: Long-term, intermittent ES injection of tA can enhance M analgesia without formation of TA in the blood.