论文部分内容阅读
氟喹诺酮类抗生素是一类广谱抗细菌药物,由于细菌耐药性降低了其他药物的疗效,使得该类药物的使用范围愈加广泛。2006年,氟喹诺酮类药物的市场份额占抗菌药物的18%。氟喹诺酮类药物最具诱惑力的特性之一是其能快速杀灭细菌,而且其各种衍生物的这一性质相差甚远。由于喹诺酮类药物在杀灭细菌时为需氧代谢,而且蛋白质合成抑制剂对其致死性有一定影响,导致不同喹诺酮类衍生物在杀菌速度和范围方面存在差异。阐明这些差异背后的机制将可能为鉴定大多数杀菌性喹诺酮类衍生物提供新的路径。
Fluoroquinolones are a class of broad-spectrum antibacterial drugs that have become more widely available because of their reduced resistance to other drugs. In 2006, the market share of fluoroquinolones accounted for 18% of antimicrobial drugs. One of the most attractive properties of fluoroquinolones is their ability to kill bacteria quickly, and the properties of their derivatives are far apart. Quinolones are metabolically aerobic in killing bacteria, and protein synthesis inhibitors have an impact on their lethality, leading to differences in the rate and extent of sterilization with different quinolone derivatives. The mechanism behind elucidation of these differences will likely provide a new pathway for the identification of most bactericidal quinolone derivatives.