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目的分析EB病毒感染儿童的临床特点及实验室检查情况。方法对诊断为EBV感染的76名患儿的临床表现、实验室检查进行回顾性分析。结果 76例中,<7岁70例(92.1%),≥7岁6例(7.9%),其中发热66例(86.8%),体温37.5~41℃,热程1~37d,其他常见的临床表现有咳嗽、咽痛、头痛、淋巴结肿大等。实验室异常指标包括:白细胞计数、异型淋巴细胞比例、肝酶及心肌酶定量。其中<7岁组和≥7岁组相比,年长儿头痛及肝酶增高比例明显增高,差异有统计学意义。EB病毒感染引起的疾病种类繁多,以呼吸道疾病为主(68.4%),其次为淋巴结炎、传染性单核细胞增多症等。结论儿童EB病毒感染可引起多种疾病,临床表现及体征多种多样,可累及全身多个系统,而年长儿更容易产生系统症状,EBV VCA-IgM及EB病毒DNA检测有助于表现不典型年幼患儿的早期诊断。
Objective To analyze the clinical features and laboratory tests of children infected with Epstein-Barr virus. Methods The clinical manifestations and laboratory tests of 76 children diagnosed with EBV infection were retrospectively analyzed. Results Among the 76 cases, 70 cases (92.1%) were under 7 years old and 6 cases (7.9%) were over 7 years old. Among them, 66 cases (86.8%) had fever, 37.5-41 ℃ in temperature and 1 ~ 37 days in heat. Other common clinical The performance of cough, sore throat, headache, swollen lymph nodes. Abnormal laboratory indicators include: white blood cell count, atypical lymphocyte ratio, liver enzyme and myocardial enzyme quantification. Among them, the proportion of headache and liver enzymes increased significantly in <7 years old group and> 7 years old group, the difference was statistically significant. EB virus infection caused by a wide range of diseases, mainly respiratory diseases (68.4%), followed by lymphadenitis, infectious mononucleosis and so on. Conclusions Children with EBV infection can cause many diseases. Their clinical manifestations and signs are diverse and may involve multiple systems of the whole body. Older children are more likely to develop systemic symptoms. EBV VCA-IgM and Epstein-Barr virus DNA tests may help to demonstrate Early diagnosis of typical young children.