六名受试者,20～28岁(其中一名女性),一次口服碳酸锂1.0g,定时取血0.10ml,共73小时。样品经湿法破坏后用原子吸收光谱法测定血锂浓度,得到的时间—血锂浓度曲线接近开放二室模型,估算出药物动力学参数如下;α=0.41h~(-1),β=0.04h~(-1),K=0.63~(-1),K=0.006h~(-1),CL=7.88L/h,t=4.2h,C=4.8μg/ml。 Six subjects, aged 20 to 28 years old (one of them), received 1.0 g of lithium carbonate orally once a day for a total of 0.10 hours for a total of 73 hours. After the sample was wet-destructed, the blood lithium concentration was determined by atomic absorption spectrometry. The obtained time-blood lithium concentration curve was close to the open two-compartment model and the pharmacokinetic parameters were estimated as follows: α = 0.41h -1, β = 0.04 h -1, K = 0.63 -1, K = 0.006 h -1, CL = 7.88 L / h, t = 4.2 h and C = 4.8 μg / ml.