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实验性矽肺青蒿素(蒿甲醚)治疗,50mg腹腔注射或50mg灌胃预防性治疗,肺重和肺胶原阻抑,较对照组降低显著(P<0.01),肺组织矽降低显著(P<0.01)。病后早期治疗,50mg腹腔注射或50mg灌胃较对照组肺重和肺胶原降低显著(P<0.01),肺组织矽降低亦显著,P<0.01。病理学预防治疗和病后早期治疗均比相应对照组低Ⅰ级左右。
The experimental treatment of artemisinin (artemether), prophylactic treatment with 50mg intraperitoneal injection or intragastric administration of 50mg, lung weight and pulmonary collagen suppression were significantly lower than those of the control group (P <0.01), while the reduction of silicon in the lung tissue was significant <0.01). After the illness early treatment, 50mg intraperitoneal injection or 50mg intragastrically than the control group, lung weight and lung collagen decreased significantly (P <0.01), lung tissue silicon reduction was also significant, P <0.01. Preventive and pathological treatment and early treatment of disease than the corresponding control group of about Ⅰ.