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目的:研究首次确诊中老年2型糖尿病患者血清胰岛素样生长因子-1(IGF-1)、胱抑素C(Cys-C)、白细胞介素(IL)-6水平与动脉粥样硬化的相关性。方法:收集来我院就诊的首次确诊2型糖尿病206例,按照彩色多普勒超声心动图检查结果无斑块或无增厚者为对照组(n=105)和有斑块或增厚者为试验组(n=101),收集一般资料及空腹血糖、餐后两小时血糖、糖化血红蛋白、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯、总胆固醇、IGF-1、Cys-C、IL-6及高敏C反应蛋白(hs-CRP)。计算体重指数(BMI)。结果:对照组颈动脉内膜中层厚度(CIMT)及血清IGF-1、hs-CRP、Cys-C、IL-6与试验组比较差异无统计学意义(P<0.05)。多元逐步回归分析结果显示CIMT与IGF-1呈负相关(r=-0.493,P<0.01),与Cys-C、IL-6及hs-CRP呈正相关(r=0.464,r=0.219,r=0.618,P<0.01)。结论:Cys-C、IL-6可能是动脉粥样硬化的独立危险因素,联合测定血清Cys-C、IL-6及IGF-1水平对预测新诊断2型糖尿病患者动脉粥样硬化可能更优。
AIM: To investigate the relationship between serum insulin-like growth factor-1 (IGF-1), cystatin C (Cys-C), interleukin (IL) -6 and atherosclerosis in the first diagnosis of type 2 diabetes mellitus in middle- Sex. Methods: Totally 206 cases with type 2 diabetes diagnosed for the first time were collected from our hospital. According to the results of color Doppler echocardiography, no or no thickening was taken as control group (n = 105) and those with plaque or thickening In the experimental group (n = 101), general data and fasting blood glucose, blood glucose, glycosylated hemoglobin, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride , Total cholesterol, IGF-1, Cys-C, IL-6 and high-sensitivity C-reactive protein (hs-CRP). Body mass index (BMI) was calculated. Results: The carotid intima-media thickness (CIMT), serum IGF-1, hs-CRP, Cys-C and IL-6 in the control group were not significantly different from those in the test group (P <0.05). Multiple regression analysis showed that CIMT was negatively correlated with IGF-1 (r = -0.493, P <0.01), and positively correlated with Cys-C, IL-6 and hs-CRP (r = 0.464, 0.618, P <0.01). Conclusions: Cys-C and IL-6 may be independent risk factors for atherosclerosis. The combined determination of serum Cys-C, IL-6 and IGF-1 levels may be better for predicting atherosclerosis in newly diagnosed type 2 diabetic patients .