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目的探讨小关节焦磷酸钙沉积症(CPPD)的临床特点、病理特征、诊断及鉴别诊断要点。方法对2013年3月-9月收治的4例CPPD患者的临床特点及病理学特征进行总结分析。结果光学显微镜下病灶出现明显钙化伴不定形及晶体物质沉积,初诊均考虑非特异性钙化病变,经偏振光显微镜检查可见有特征性的双折光性菱形晶体确诊CPPD;其中1例合并有针状结晶,提示合并痛风。结论 CPPD较少见,普通组织形态无特异性,医生需结合病理检查(包括偏振光显微镜检查)及临床表现综合判断,以防漏诊或误诊。
Objective To investigate the clinical features, pathological features, diagnostic and differential diagnosis points of small joint calcium pyrophosphate deposition (CPPD). Methods The clinical features and pathological features of 4 patients with CPPD admitted from March to September in 2013 were analyzed. Results The lesions under the optical microscope showed obvious calcification with amorphous and crystalline substance deposition. The non-specific calcification lesions were considered in the first visit. The CPPD was confirmed by polarized light microscopy. One of them had acicular crystals , Suggesting that gout. Conclusions CPPD is rare, the general morphology of the tissue is not specific, doctors need to combine pathological examination (including polarized light microscopy) and clinical judgments to prevent misdiagnosis or misdiagnosis.