丁胺卡那霉素对绝大多数革兰氏阴性菌包括绿脓杆菌引起的感染都有良好的疗效。它的杀菌作用依赖于三个因素:1.血清药峰浓度,2.血清药峰浓度与最小抑菌浓度的比值,3.用后的效果。有人报告每天1次丁胺卡那霉素显著降低患者肾脏和前庭的毒害。因此,作者即在结肠直肠外科中将每日1次丁胺卡那霉素联用甲硝唑与每日2 Amikacin has a good effect on most Gram-negative bacteria, including infections caused by Pseudomonas aeruginosa. Its bactericidal effect depends on three factors: 1. Serum drug concentration, 2. Serum drug concentration and the minimum inhibitory concentration ratio, 3. The effect after use. It has been reported that once daily amikacin significantly reduces the toxicity of the kidneys and vestibules of patients. Therefore, the authors in the colorectal surgery once daily amikacin metronidazole combined with daily 2