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目的初步研究维思通治疗精神分裂症的疗效和不良反应，以及ＰＡＮＳＳ的临床适用性。方法２０例病人用维思通治疗八周，用ＰＡＮＳＳ、ＣＧＩ和ＧＡＳ评定疗效，ＥＳＲＳ和实验室检查评价不良反应。结果维思通对阳性和阴性分裂症状有效，起效较快。不良反应有轻度锥外反应和激越。ＰＡＮＳＳ的平行效度和内部一致性尚可。结论维思通对精神分裂症有效且安全性高。ＰＡＮＳＳ适合做为精神分裂症的评定工具
Objective To study the efficacy and adverse reactions of VST in the treatment of schizophrenia and the clinical applicability of PANSS. Methods Twenty patients were treated with VST for eight weeks. Efficacy was assessed by PANSS, CGI and GAS. ESRS and laboratory tests were performed to evaluate the adverse effects. Results VST on the positive and negative schizophrenia symptoms effectively. Adverse reactions with mild extrapyramidal reactions and agitation. The parallel validity and internal consistency of PANSS are acceptable. Conclusion VST is effective and safe to schizophrenia. PANSS is suitable as a schizophrenia assessment tool