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[目的]探讨不同症型肠易激综合征(IBS)患者血清中白细胞介素-1β(IL-1β)、IL-10、IL-18和肿瘤坏死因子-α(TNF-α)的表达变化及在IBS发病机制中的作用.[方法]72例IBS患者根据症状类型分为腹泻型IBS组(A组)和便秘型IBS组(B组),采用ELISA法检测比较患者血清中细胞因子IL-1β、IL-10、IL-18和TNF-α含量.[结果]A组和B组IL-1β、IL10、IL-18和TNF-α在血清中的表达与对照组比较均明显升高,且差异有显著性(P<0.05).A组TNF-α水平明显高于B组,且差异有显著性(P0.05).[结论]促炎性细胞因子和抗炎性细胞因子的失衡可能与IBS患者腹泻、腹胀、排便习惯改变等临床症状的出现具有一定的相关性.“,”[Objective]To investigate the changes of serum interleukin-1β(IL-1β)、IL-10、IL-18 and tumor necrosis factor alpha (TNF-) expression in patients with irritable bowel syndrome (IBS) and their roles in the pathogenesis of IBS.[Methods] Seventy-two patients with IBS were divided into diarrhea type group IBS (group A) and constipation type IBS group (B group) according to the symptom type.The levels of cytokines IL-1β, IL-10, IL-18 and TNF-αin serum were detected by ELISA.[Results]The expression of IL-1β、IL-10、IL-18 and TNF-αin serum of the Group A and the Group B was significantly higher than those of the control group, and the difference was significant (P<0.05).The level of TNF-αin the Group A was higher than that in the Group B, and the difference was significant (P0.05).[Conclusion]The imbalance between proinflammatory cytokines and anti-inflammatory cytokines may be related to the clinical symptoms such as diarrhea, abdominal distension, and changes in bowel habits in IBS patients.