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环氧合酶-2(Cyclooxygenase-2,COX-2)是前列腺素合成过程中一重要的限速酶,COX-2的过度表达及其前列腺素产物与多种肿瘤的发生、发展关系密切,COX-2抑制剂通过抑制肿瘤细胞增殖,诱导肿瘤细胞凋亡,阻断致癌物的代谢,减弱肿瘤介导的免疫抑制,调节抑制血管生成,抑制肿瘤细胞侵袭,环氧合酶非依赖抑癌途径,对原癌基因及抑癌基因的影响等途径影响肿瘤的发生发展,这方面的研究为针对COX-2的抗肿瘤策略打开新的视野,提供新的线索。
Cyclooxygenase-2 (COX-2) is an important rate-limiting enzyme in prostaglandin synthesis. Overexpression of COX-2 and its prostaglandin products are closely related to the occurrence and development of many tumors. COX-2 inhibitors inhibit tumor-mediated immunosuppression, inhibit angiogenesis, inhibit tumor cell invasion, and cyclooxygenase-independent tumor suppressor by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, blocking the metabolism of carcinogens, Pathways, on the proto-oncogene and tumor suppressor genes and other ways affect the occurrence and development of tumors, this study for the COX-2 anti-tumor strategy to open a new horizons, to provide new clues.