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磁性纳米粒子,是一类智能型的纳米材料,因其特有的性质,被广泛应用于生物医学领域,在肝癌的治疗方面也有大量的实验性研究和成果。研究和探索磁性纳米粒子治疗肝癌的新方法和途径,有着很大的现实意义。本文就磁性纳米粒子作用于肝癌细胞的生物学效应的研究现状和进展进行总结整理,从三个方面进行了综述:磁性纳米粒子直接作用于肝癌细胞,探索磁性纳米粒子的生物相容性、在肝癌细胞的分布方式以及磁性纳米粒子本身对肝癌细胞的生物学效应的影响;磁性纳米粒子协同外加磁场(稳恒磁场、极低频交变磁场和高频交变磁场)作用于肝癌细胞;磁性纳米粒子外加修饰(磁性白蛋白纳米颗粒、纳米磁流体、磁性脂质体等),作为药物载体作用于肝癌细胞。
Magnetic nanoparticles, a type of intelligent nanomaterials, are widely used in the field of biomedicine due to their unique properties. There are also many experimental researches and achievements in the treatment of liver cancer. Research and exploration of magnetic nanoparticles for the treatment of liver cancer new methods and approaches, has great practical significance. In this paper, the current situation and progress of the biological effects of magnetic nanoparticles on hepatocellular carcinoma cells are summarized and summarized from three aspects: the magnetic nanoparticles directly act on the liver cancer cells to explore the biocompatibility of magnetic nanoparticles in The distribution of hepatoma cells and the effect of magnetic nanoparticles on the biological effects of hepatocellular carcinoma cells; magnetic nanoparticles in combination with applied magnetic field (stable magnetic field, very low frequency alternating magnetic field and high frequency alternating magnetic field) on liver cancer cells; magnetic nano Modified particles (magnetic albumin nanoparticles, nano-magnetic fluid, magnetic liposomes, etc.), acting as a drug carrier in liver cancer cells.