[目的]制备多种酰胺类农药的一个重要中间体N-羟甲基-2-三氟甲基苯甲酰胺。[方法]以邻三氟甲基苯甲醛为起始原料,经氧化反应得到邻三氟甲基苯甲酸,然后与氯化亚砜、氨气经氯化及胺化得到邻三氟甲基苯甲酰胺,最后经羟甲基化得到N-羟甲基-2-三氟甲基苯甲酰胺。目标化合物及中间体结构经1H N M R确证。[结果]反应总收率66.6%,产品含量98.5%。[结论]该工艺收率高,操作简单,可为工业化生产提供参考。 [Objective] The research aimed to prepare N-methylol-2-trifluoromethylbenzamide, one of the important intermediates of various amide pesticides. [Method] With o-trifluoromethylbenzaldehyde as starting material, o-trifluoromethylbenzoic acid was obtained through oxidation reaction, and then chlorinated and aminated with thionyl chloride to obtain o-trifluoromethylbenzene Formamide and finally methylolated to give N-methylol-2-trifluoromethylbenzamide. The target compounds and intermediates were confirmed by 1H NMR. [Result] The total reaction yield was 66.6% and the product content was 98.5%. [Conclusion] The process has high yield and easy operation, which can provide reference for industrial production.