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男性不育症是世界范围内困扰许多育龄夫妇的一个重要问题。在诊断方面,多种男科学实验室诊断新技术逐渐应用于临床:计算机辅助精子分析技术(CASA)已经得到了广泛的应用,脱氧核糖核苷酸末端转移酶介导的缺口末端标记法(TUNEL)和流式细胞术(FCM)已被应用于生精细胞凋亡的检测,抑制素B水平的检测为不育患者生育力的评估提供了一种有效的血清学指标,同时,遗传学检测、精子功能检测等也被应用于临床。在治疗方面,辅助生育技术,尤其是胞浆内单精子注射(ICSI)的成功应用,为男性不育提供了一种有效的治疗手段,结合严格的遗传学检测,ICSI可以认为是安全的,另外,ICSI的应用也使男性不育症的治疗策略有了很大改变,男科学家的注意力已从提高精子密度和活力方面转移到提高精子质量方面。
Male infertility is an important problem that plagues many couples of childbearing age worldwide. In the field of diagnosis, a variety of new diagnostic techniques for gynecological laboratories have been gradually applied to clinical practice. Computer-assisted sperm analysis (CASA) has been widely used. Deoxyribonucleotide end-transferase-mediated nick end labeling (TUNEL ) And flow cytometry (FCM) have been used in the detection of apoptosis of spermatogenic cells. The detection of inhibin B level provides an effective serological indicator for the assessment of fertility in infertile patients. At the same time, genetic testing , Sperm function test also been applied to clinical. In the area of treatment, the successful application of assisted reproductive technology, especially intracytoplasmic sperm injection (ICSI), provides an effective treatment for male infertility. Combined with rigorous genetic testing, ICSI can be considered as safe, In addition, the use of ICSI has greatly changed the therapeutic strategy of male infertility. The attention of male scientists has shifted from increasing sperm density and vitality to improving sperm quality.