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目的:通过观察肝硬化失代偿期患者血清胱抑素c(Cystatin c,Cys c)水平变化,探讨Cys c与肝硬化失代偿及并发出血、腹水的关系。方法:应用颗粒增强透射免疫比浊法测定32名肝硬化失代偿期患者及32名健康对照者血清Cys c值,分析肝硬化及并发出血、腹水与Cys c的关系。结果:肝硬化失代偿组Cys c浓度明显高于正常对照组,肝硬化腹水组Cys c浓度明显高于肝硬化无腹水组,且发现肝硬化失代偿组与正常对照组比较,Cys c浓度与年龄有更为显著的正相关性趋势。结论:血清Cys c对肝硬化的发生、发展及腹水的形成有一定的作用,且肝硬化失代偿期患者血清Cys c更易受年龄增长的影响。
Objective: To observe the changes of serum Cystatin C (Cys c) levels in patients with decompensated cirrhosis and to explore the relationship between Cys c and decompensation of liver cirrhosis and concurrent hemorrhage and ascites. Methods: Serum Cys c values of 32 patients with decompensated liver cirrhosis and 32 healthy controls were measured by particle - enhanced immunoturbidimetry. The relationship between cirrhosis and hemorrhage, ascites and Cys c was analyzed. Results: The Cys c concentration in decompensated cirrhosis group was significantly higher than that in normal control group. The Cys c concentration in cirrhotic ascites group was significantly higher than in cirrhosis without ascites group. Compared with normal control group, Cys c Concentration and age have a more significant positive correlation trend. Conclusion: Serum Cys c may play an important role in the occurrence and development of cirrhosis and the formation of ascites. The serum Cys c in patients with decompensated cirrhosis is more likely to be influenced by the age.