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目的比较曲克芦丁脑蛋白水解物和脑苷肌肽治疗新生儿缺氧缺血性脑病的临床疗效。方法收集2013年1月—2015年1月在东方医院诊治的新生儿缺氧缺血性脑病患者120例,随机分为对照组和治疗组,每组各60例。对照组静脉滴注脑苷肌肽注射液,2 m L加入到5%葡萄糖注射液50 m L中,1次/d。治疗组静脉滴注曲克芦丁脑蛋白水解物注射液,0.5m L/(kg·d)加入到5%葡萄糖注射液50 m L中。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组新生儿行为神经(NBNA)评分、意识恢复时间、肌张力恢复时间和原始反射恢复时间。对患儿进行6个月随访,记录两组患儿恢复正常,发生智力低下、癫痫、脑瘫的情况。结果治疗后,对照组和治疗组的总有效率分别为86.67%、95.00%,两组比较差异具有统计学意义(P<0.05)。两组患儿治疗3、7、14天NBNA评分比较差异均无统计学意义。治疗组患儿意识恢复时间、肌张力恢复时间、原始反射恢复时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组患儿恢复率显著高于对照组,智力低下发生率、癫痫发生率、脑瘫发生率均低于对照组,两组比较差异具有统计学意义(P<0.05)。结论曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果显著,可缩短临床恢复时间,显著改善患儿随访结果,具有一定的临床推广应用价值。
Objective To compare the clinical efficacy of troxerutin and cinobufagin in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods 120 cases of neonatal hypoxic-ischemic encephalopathy diagnosed and treated in Dongfang Hospital from January 2013 to January 2015 were randomly divided into control group and treatment group, 60 cases in each group. Control group intravenous injection of sis glycoside, 2 m L added to 5% glucose injection 50 m L, 1 / d. The treatment group was given intravenous infusion of troxerutin, and 0.5 m L / (kg · d) was added to 50 mL of 5% glucose injection. Both groups were treated for 14 days. The clinical curative effect of the two groups was observed. At the same time, NBNA score, consciousness recovery time, muscle tone recovery time and original reflex recovery time were compared between the two groups. The patients were followed up for 6 months, and the children in both groups returned to normal with mental retardation, epilepsy and cerebral palsy. Results After treatment, the total effective rates of the control group and the treatment group were 86.67% and 95.00%, respectively, with statistical significance (P <0.05). There was no significant difference in NBNA score between the two groups on 3, 7 and 14 days. The recovery time, muscle tone recovery time and original reflex recovery time in treatment group were significantly shorter than those in control group, with significant difference between the two groups (P <0.05). The recovery rate of children in the treatment group was significantly higher than that of the control group. The incidence of mental retardation, epilepsy and cerebral palsy were both lower than those in the control group. There was significant difference between the two groups (P <0.05). Conclusion The clinical effect of Treating Hypoxic Ischemic Encephalopathy with Troxerutin is significant, which can shorten the clinical recovery time and significantly improve the follow-up results of children with certain clinical application value.