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目的了解章丘市≤15岁健康人群埃可病毒30型(ECHO30)的人群感染情况。方法用中和抗体检测技术测定血清抗体水平。结果章丘市存在ECHO30所致无菌性脑膜炎的爆发,≤15岁健康人群中和抗体几何平均滴度(GMT)为1∶53.08,非常显著地高于非流行区的GMT(1∶32.45)。流行区中和抗体滴度集中分布在1∶64~1∶256(36.52%),年龄别抗体水平有差异,≥3岁人群随着年龄的增长,抗体水平呈下降趋势。非流行区人群血清中和抗体水平无年龄别差异。结论ECHO30所致疾病流行后,人群具有一定的免疫力;非流行区未出现该毒株所致疾病的流行。
Objective To understand the population infection of ECHO30 in healthy population of ≤15 years old in Zhangqiu City. Methods Serum antibody levels were measured by neutralizing antibody assay. Results There was an outbreak of aseptic meningitis caused by ECHO30 in Zhangqiu City. The geometric mean titer (GMT) of neutralizing antibodies in healthy people ≤15 years old was 1:53.08, which was significantly higher than that of non-endemic area (1:32.45 ). The titers of neutralizing antibodies in epidemic areas were mainly distributed in the range of 1:64 to 1:256 (36.52%). There was a difference in antibody levels between ages. The antibody levels of ≥3-year-old population decreased with age. Non-endemic areas of serum levels of neutralizing antibodies without age difference. Conclusions ECHO30-induced disease epidemic, the population has a certain immunity; non-endemic areas did not appear that the strains caused by the epidemic.