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目的探讨糖尿病患者微量白蛋白尿进展为严重肾病的危险因素。方法随机选取120例2型糖尿病患者为研究对象,根据尿白蛋白的排泄值分为3组:正常白蛋白尿组,尿白蛋白排泄值低于30mg/d;微量白蛋白尿组:尿白蛋白排泄值30-300mg/d;临床白蛋白尿组,尿白蛋白排泄值大于300mg/d;并以同期健康体检成人135例作为对照组。结果糖尿病组的MAU,HBA1C,FPG,LDL,TG,TC的浓度显著高于正常对照组(P<0.01),HDL的浓度显著低于正常对照组(P<0.05),MAU危险因素统计分析结果表明MAU与糖尿病病程,SP,DP,TG,TC,HDL,Cr呈正相关,而与年龄,体重指数(BMI),HBA1C,BUN等无相关性。结论 2型糖尿病患者中MAU的发生率为23.3%,糖尿病病程,SP,DP,TG,TC,HDL,Cr与2型糖尿病患者发生MAU密切相关。MAU的出现常能够反映肾脏功能和结构的轻度受损。
Objective To investigate the risk factors for progression of microalbuminuria in diabetic patients to severe nephropathy. Methods A total of 120 patients with type 2 diabetes mellitus were enrolled in this study. According to the urinary albumin excretion, they were divided into 3 groups: normal albuminuria group, urinary albumin excretion less than 30mg / d; microalbuminuria group: urinary white Protein excretion 30-300mg / d; clinical albuminuria, urinary albumin excretion greater than 300mg / d; and the same period, 135 healthy adults as control group. Results The concentrations of MAU, HBA1C, FPG, LDL, TG and TC in diabetic group were significantly higher than those in normal control group (P <0.01). The concentrations of HDL in diabetic group were significantly lower than those in normal control group (P <0.05) The results showed that there was a positive correlation between MAU and duration of diabetes mellitus, SP, DP, TG, TC, HDL and Cr, but no correlation with age, BMI, HBA1C and BUN. Conclusions The incidence of MAU in type 2 diabetic patients is 23.3%. The duration of diabetes mellitus, SP, DP, TG, TC, HDL and Cr are closely related to the occurrence of MAU in type 2 diabetic patients. The appearance of MAU often reflects mild impairment of renal function and structure.