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多数学者认为,溃疡性结肠炎(UC)与免疫机能障碍、遗传、感染及精神因素等有关。近年更多注意到UC与免疫机能异常和炎症介质生成增多密切相关。若能阻制免疫反应和特异受体作用,减少或抑制前列腺素样物质、白三烯、血小板活化因子、细胞激活因子、氧自由基、神经多肽、P物质、血管活性肽等,均可能使病情有所缓解。治疗UC首先应注意饮食调节,必要时进行TPN,改善全身状况,解除精神因素及对症治疗。目前,柳氮磺胺吡啶(SASP)、5-氨基水杨酸(5-ASA)及皮质类固醇仍为治疗UC的主药。 1.氨基水杨酸类:SASP口服达结肠后,经肠道菌的偶氮还原酶裂解为5-ASA和碘胺吡啶,前者
Most scholars believe that ulcerative colitis (UC) and immune dysfunction, genetic, infection and mental factors related. In recent years more attention to UC and immune dysfunction and increased production of inflammatory mediators are closely related. If the immune response can be inhibited and specific receptor, reducing or inhibiting prostaglandin-like substances, leukotrienes, platelet activating factor, cell activating factor, oxygen free radicals, neuropeptides, substance P, vasoactive peptides, may be The condition has eased. Treatment of UC should first pay attention to diet regulation, if necessary, TPN to improve the general condition, relieve the psychological factors and symptomatic treatment. Currently, sulfasalazine (SASP), 5-aminosalicylic acid (5-ASA) and corticosteroids are still the main drug for the treatment of UC. 1. Aminosalicylates: SASP oral up to the colon, the intestinal bacteria by azo reductase cleavage 5-ASA and iodine pyridine, the former