β 内酰胺酶抑制剂和 β 内酰胺类抗生素的联合应用是当前比较成功的一种对抗特殊耐药机制的策略。细菌耐药性不断增加是一个全球性的严峻问题 ,因此药物直接靶向作用和逆转耐药机制显得十分重要。β 内酰胺酶水解 β 内酰胺环中的酰胺键 ,并且阻止活性药物与靶部位青霉素结合 The combination of β-lactamase inhibitors and β-lactam antibiotics is currently a more successful strategy to combat specific resistance mechanisms. Increasing bacterial resistance is a serious global problem. Therefore, direct drug targeting and reversing drug resistance mechanisms are very important. Beta-lactamases hydrolyze amide bonds in the beta-lactam ring and prevent the active drug from binding to the target site of penicillin