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目的:利用近红外光谱快速鉴别盐酸左西替利嗪片的真伪。方法:在4 200～10 000 cm~(-1)范围内对盐酸左西替利嗪片进行全谱扫描,建立一致性检验模型,并对图谱进行比对分析。结果:正品盐酸左西替利嗪片与其伪品存在着较大差别,利用一致性检验模型及图谱比对法均可以判断。结论:所用方法快速、简便、准确、有效,是基层查处假冒大品牌药品的有效手段。
Objective: To quickly identify the authenticity of levocetirizine hydrochloride tablets by near infrared spectroscopy. Methods: The levocetirizine hydrochloride tablets were scanned in the range of 4 200 ~ 10 000 cm ~ (-1) to establish the consistency test model and to compare the profiles. Results: There was a big difference between the genuine levocetirizine hydrochloride tablets and its counterfeit products, which could be judged by the consistency test model and the map comparison method. Conclusion: The method used is quick, easy, accurate and effective. It is an effective means for investigating and dealing with counterfeit big brand drugs at the grassroots level.