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目的:观察强心宁煎剂联合曲美他嗪对慢性心衰左心室功能及血浆心钠素、内皮素水平的影响。方法:选取2013年2月~2015年1月我院心内科收治的62例慢性心衰患者为研究对象,随机数字表法分为研究组和对照组各31例,对照组给予强心宁煎剂治疗,研究组在对照组基础上另联合曲美他嗪治疗,对两组治疗后临床疗效、左心室功能[左心室射血分数(LVEF)、左室舒张末期内径(LVDd)、左室收缩末期容量(LVESV)]、血浆心钠素(ANP)、血浆内皮素(ET)及药物不良反应进行观察比较。结果:两组治疗后研究组临床总有效率87.10%较对照组62.07%显著高(P<0.05);两组治疗后LVEF较治疗前显著升高,LVDd、LVESV显著下降,且治疗后研究组LVEF较对照组升高显著,LVDd、LVESV降低显著,均具有统计学意义(P<0.05);两组治疗后ANP、ET分别均较治疗前降低,仅ANP治疗前后有显著差异(P<0.05),且治疗后研究组ANP、ET分别均较对照组降低显著,均具有统计学意义(P<0.05);两组药物不良反应比较无显著差异(P>0.05)。结论:强心宁煎剂联合曲美他嗪对慢性心衰患者具有较好的临床疗效,且对左心室功能、血浆心钠素、内皮素水平均具有显著改善作用。
Objective: To observe the effects of Qiangxinning decoction combined with trimetazidine on left ventricular function and plasma atrial natriuretic peptide and endothelin levels in patients with chronic heart failure. Methods: Sixty-two patients with chronic heart failure admitted to our hospital from February 2013 to January 2015 were enrolled in this study. The random number table was divided into study group (31 cases) and control group (n = 31). The control group The study group was treated with trimetazidine combined with trimetazidine on the basis of the control group. The clinical efficacy, left ventricular function (left ventricular ejection fraction, left ventricular end-diastolic diameter, LVDd, End systolic volume (LVESV)], plasma atrial natriuretic peptide (ANP), plasma endothelin (ET) and adverse drug reactions were observed and compared. Results: After treatment, the total effective rate of the study group was 87.10%, which was significantly higher than that of the control group (62.07%, P <0.05). The LVEF of the two groups was significantly higher than that before treatment, while the LVDd and LVESV were significantly decreased LVEF increased significantly compared with the control group, LVDd, LVESV decreased significantly (P <0.05), the ANP and ET of the two groups were lower than before treatment, and there was significant difference only before and after ANP treatment (P <0.05 ). After treatment, the levels of ANP and ET in the study group were significantly lower than those in the control group (P <0.05). There was no significant difference in adverse drug reactions between the two groups (P> 0.05). CONCLUSION: Combination of QXN decoction with trimetazidine has good clinical efficacy in patients with chronic heart failure, and has significant effect on left ventricular function, plasma atrial natriuretic peptide and endothelin levels.