论文部分内容阅读
目的:探讨GP73在肝癌组织中的表达及其与患者临床病理特征的关系。方法:采用RT-PCR及Western blot方法检测20例肝癌、相应癌旁组织和10例正常肝组织中GP73 mRNA及蛋白的表达情况,并分析其表达水平与临床病理特性的关系。结果:肝癌组织中,GP73 mRNA与蛋白表达水平均明显高于癌旁组织和正常肝组织(1.25±0.17 vs.0.62±0.06,0.46±0.03;2.20±0.26 vs.0.87±0.07,0.26±0.04)(均P<0.05);GP73 mRNA及蛋白的表达水平在血管有无侵犯及肿瘤分化程度分组间差异有统计学意义,有血管侵犯和肿瘤分化低者GP73表达水平高于无侵犯及分化高者(均P<0.05),而与患者年龄、性别、肿瘤大小、肿瘤数目及血清甲胎蛋白(AFP)水平无明显关系(均P>0.05)。结论:GP73在肝癌组织中高表达,其表达水平与肝癌侵袭性密切相关;它有望成为新的判断肝癌侵袭性及术后转移复发的标志物。
Objective: To investigate the expression of GP73 in hepatocellular carcinoma and its relationship with clinicopathological features. Methods: The expression of GP73 mRNA and protein in 20 cases of HCC, corresponding paracancerous tissues and 10 cases of normal liver tissues were detected by RT-PCR and Western blot. The relationship between the expression of GP73 mRNA and protein and the clinicopathological features was analyzed. Results: The expressions of GP73 mRNA and protein in hepatocellular carcinoma tissues were significantly higher than those in paracancer tissues and normal liver tissues (1.25 ± 0.17 vs.0.62 ± 0.06, 0.46 ± 0.03; 2.20 ± 0.26 vs.0.87 ± 0.07, 0.26 ± 0.04, respectively) (All P <0.05). There were significant differences in the expression of GP73 mRNA and protein between the groups with or without vascular invasion and tumor differentiation. The GP73 expression levels in patients with low vascular invasion and tumor differentiation were higher than those without invasion and differentiation (All P <0.05), but not with the age, gender, tumor size, tumor number and serum AFP level (all P> 0.05). Conclusion: GP73 is highly expressed in HCC and its expression level is closely related to the invasiveness of HCC. It is expected to become a new marker of invasion and recurrence of HCC.