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目的探讨对腹泻型肠易激综合征患者采用马来酸曲美布丁联合布拉酵母菌治疗的临床效果。方法选取信阳市中心医院2013年12月至2016年1月收治的腹泻型肠易激综合征患者92例,采用随机数字法分为对照组(n=45)和观察组(n=47)。对照组采用马来酸曲美布丁治疗,观察组采用马来酸曲美布丁联合布拉酵母菌治疗,比较两组腹泻次数、止泻时间、急性应激次数、治疗总有效率及不良反应。结果观察组腹泻次数、止泻时间、急性应激次数优于对照组,总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应。结论对腹泻型肠易激综合征患者采用马来酸曲美布丁联合布拉酵母菌治疗,能显著降低腹泻次数、急性应激次数,效果良好。
Objective To investigate the clinical efficacy of trimebutine maleate and bronulactin in patients with diarrhea-predominant irritable bowel syndrome. Methods 92 patients with diarrhea-predominant irritable bowel syndrome (IBD) admitted from December 2013 to January 2016 in Xinyang Central Hospital were divided into control group (n = 45) and observation group (n = 47) by random number method. The control group was treated with trimebutine maleate. The observation group was treated with trimebutine maleate and brassinositol. The diarrhea frequency, diarrhea time, frequency of acute stress, total effective rate and adverse reactions in both groups were compared. Results The number of diarrhea, diarrhea time and the number of acute stress in the observation group were better than those in the control group, and the total effective rate was significantly higher than that in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion The treatment of diarrhea-predominant irritable bowel syndrome with trimebutine maleate and broncoalbumin can significantly reduce the frequency of diarrhea and the number of acute stress, with good results.