以植物活性单体环维黄杨星D为先导物,设计合成了7个新型的含氮杂环的环维黄杨星D衍生物,其结构经1H NMR,HRMS和IR鉴定.初步的抗耐缺氧活性研究结果表明,合成的新化合物具有一定的抗耐缺氧活性,其中含哌嗪基取代的衍生物活性较好. Seven new heterocyclic ring-containing compounds were designed and synthesized based on the living plant ring of viaduynin D and their structures were identified by 1H NMR, HRMS and IR. The results of the oxygen activity study showed that the new compounds synthesized have certain anti-hypoxia-tolerant activity, of which the piperazine-substituted derivatives have good activity.