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1992年5月~1994年12月体外放疗50~60Gy/5~6周加高剂量率(HDR)腔内放疗10~15Gy/4~6;k/5~9天,2.5Gy/次,Bid治疗食管鳞癌56例(综合组),与同期单纯体外放疗60~70Gy/6.5~7周52例(对照组)比较。综合组1、2年生存率和2年局控率分别为76.8%、51.8%和63.5%。明显高于对照组的42.3%、28.8%和32.6%。食管X线片示病变长度≤7cm和无食管轴向异常者,综合组3年生存率分别42.3%和40.9%,明显高于对照组的14.8%和14.3%。综合组食管瘘发生率为3.6%,晚期食管良性狭窄率为7.4%。
From May 1992 to December 1994, 50 to 60 Gy/5 to 6 weeks plus high dose rate (HDR) intracavitary radiotherapy 10 to 15 Gy/4 to 6; k/5 to 9 days, 2.5 Gy/time, Bid Treatment of esophageal squamous cell carcinoma in 56 cases (comprehensive group), compared with the same period in vitro 60 ~ 70Gy/6.5 to 7 weeks (control group). The overall 1-, 2-year survival rate and 2-year control rate were 76.8%, 51.8% and 63.5%, respectively. Significantly higher than the control group 42.3%, 28.8% and 32.6%. Esophageal X-ray films showed lesion length ≤ 7cm and no axial abnormalities in the esophagus. The 3-year survival rate of the comprehensive group was 42.3% and 40.9%, respectively, which was significantly higher than the 14.8% and 14.3% of the control group. The incidence of esophageal fistula was 3.6% in the comprehensive group and 7.4% in the advanced esophageal stricture.