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子宫颈癌是妇科常见的恶性肿瘤之一。人乳头状瘤病毒(human papilloma virus,HPV)的持续感染与子宫颈癌的发生密切相关。HPV疫苗在预防和治疗宫颈癌方面备受关注。HPV疫苗能激发机体的细胞和体液免疫应答,有效的预防和控制HPV感染,在预防和治疗宫颈癌方面发挥作用。新型预防性HPV疫苗已在多个国家已经上市;多肽疫苗、蛋白疫苗、病毒载体疫苗、DNA疫苗等治疗性疫苗的研究也有新的进展。现对HPV疫苗在预防和治疗子宫颈癌方面的最新研究进展做一综述。
Cervical cancer is one of the common gynecological malignancies. The persistent infection of human papilloma virus (HPV) is closely related to the occurrence of cervical cancer. HPV vaccines have drawn much attention in the prevention and treatment of cervical cancer. HPV vaccine can stimulate the body’s cellular and humoral immune response, effective prevention and control of HPV infection, in the prevention and treatment of cervical cancer play a role. New prophylactic HPV vaccine has been listed in many countries; peptide vaccines, protein vaccines, viral vector vaccines, DNA vaccines and other therapeutic vaccines research has also made new progress. The recent progress of HPV vaccine in the prevention and treatment of cervical cancer is reviewed.