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目的:探讨脂联素(APN)与转化生长因子-β1(TGF-β1)水平早期预测妊娠期糖尿病(GDM)发生的临床价值。方法:选取妊娠14~20周的孕妇采空腹静脉血,并随访至妊娠24~28周行75g糖耐量试验(OGTT)。选取其中40例OGTT正常者为对照组,38例GDM孕妇为试验组。比较2组血清脂联素、TGF-β1及血糖、胰岛素水平。结果:GDM组脂联素水平显著低于对照组(p<0.01),TGF-β1水平显著高于对照组(p<0.01)。GDM组脂联素与胰岛素呈负相关,TGF-β1与胰岛素呈正相关。结论:GDM患者血清脂联素与TGF-β1的变化早于血糖的改变,可作为早期预测GDM的因子,有一定的临床价值。
Objective: To investigate the clinical value of early detection of gestational diabetes mellitus (GDM) with adiponectin (APN) and transforming growth factor-β1 (TGF-β1) levels. Methods: Pregnant women with fasting blood from 14 to 20 weeks of gestation were selected for fasting blood glucose, and 75g glucose tolerance test (OGTT) was followed up until 24 to 28 weeks gestation. Forty patients with normal OGTT were selected as the control group and 38 pregnant women with GDM as the experimental group. Serum adiponectin, TGF-β1, blood glucose and insulin levels were compared between the two groups. Results: The level of adiponectin in GDM group was significantly lower than that in control group (p <0.01), TGF-β1 level was significantly higher than that in control group (p <0.01). GDM group was negatively correlated with insulin and TGF-β1 was positively correlated with insulin. Conclusion: The changes of serum adiponectin and TGF-β1 in patients with GDM are earlier than the changes of blood glucose, which may be used as an early predictor of GDM and have certain clinical value.