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目的 评价单纯疱疹病毒性角膜炎患者行穿透性角膜移植术后,口服阿昔洛韦预防单纯疱疹病毒性角膜炎复发的疗效。方法 1999年1月至2 0 0 3年12月单纯疱疹病毒性角膜炎5 2例5 2眼行穿透性角膜移植术,术后给予口服阿昔洛韦2 0 0mg 5次/d ,服用2m～3m后减为4 0 0mg 2次/d ,继续服用3m后停止,分析单纯疱疹病毒性角膜炎复发的情况。结果 在口服阿昔洛韦期间,无一例出现单纯疱疹病毒性角膜炎的复发。术后经12m～38m (2 2 .8±9. 6 )的随访,4 9眼植片透明,3眼因排斥反应植片混浊。32眼(6 1 .5 % )最佳矫正视力好于0 . 5 ,4 9眼(94 . 2 % )最佳矫正视力好于0 . 1,3眼(5 . 8% )低于0 . 1。结论 口服阿昔洛韦能有效预防单纯疱疹病毒性角膜炎行穿透性角膜移植术后的复发
Objective To evaluate the efficacy of oral administration of acyclovir to prevent the recurrence of herpes simplex virus keratitis after penetrating keratoplasty in patients with herpes simplex virus keratitis. Methods From January 1999 to December 2003 herpes simplex keratitis 52 cases 52 cases of penetrating keratoplasty, after oral administration of acyclovir 200 mg 5 times / d, taking 2m ~ 3m and then reduced to 400mg 2 times / d, continue to take 3m stop after the analysis of herpes simplex virus keratitis recurrence. Results During the oral acyclovir, no case of herpes simplex virus keratitis recurrence. After follow-up 12m ~ 38m (22.8 ± 9.6), 49 eyes were transparent and 3 eyes were opaque due to rejection. The best corrected visual acuity was better than 0.5, 49 eyes (94.2%) in 32 eyes (61.5%). The best corrected visual acuity was better than 0. 1,3 (5. 8%) lower than 0. 1. Conclusion Oral acyclovir can effectively prevent the recurrence of herpes simplex virus keratitis after penetrating keratoplasty