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目的：研究伏隔核（ＮＡｃ）中多巴胺（ＤＡ）神经末梢在二氢埃托啡（ＤＨＥ）精神依赖性中的作用。方法：采用条件性位置偏爱实验反映ＤＨＥ的精神依赖性。结果：ＤＨＥ（０．５μｇ·ｋｇ－１，ｓｃ）单独给药产生显著的位置偏爱效应。用６－羟多巴胺（６－ＯＨＤＡ）选择性损毁ＮＡｃ的ＤＡ能神经元末梢后，大鼠则不能对ＤＨＥ形成偏爱效应。结论：ＮＡｃ中ＤＡ神经元的完整性是ＤＨＥ产生偏爱效应所必需的
AIM: To investigate the role of dopamine (DA) nerve terminals in the nucleus accumbens (NAc) in the psychic dependence of dihydroetorphine (DHE). Methods: The conditional place preference test reflects the spiritual dependence of DHE. Results: DHE alone (0.5 μg · kg -1, sc) produced a significant place preference effect. Selective damage of DAc neurons in NAc by 6-hydroxydopamine (6-OHDA) did not result in a preference effect on DHE. CONCLUSION: The integrity of DA neurons in NAc is required for the production of a preference effect by DHE