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目的和方法：利用免疫组化技术ＬＳＡＢ法和计算机图像分析系统的结合，测定经手术病理证实之３７例肺鳞癌及４８例肺腺癌组织中ｃ－ｅｒｂＢ－２及ｂｃｌ－２基因蛋白的表达水平，分析其表达或共表达与反映肺癌侵袭力的影像征象的关系。结果：ｃ－ｅｒｂＢ－２及ｂｃｌ－２基因蛋白在两种不同类型肺癌组织中的阳性表达及表达定位有明显的差异，并且，ｃ－ｅｒｂＢ－２基因蛋白表达阳性的肺癌，肿块毛刺征的出现率明显高于表达阴性者；ｂｃｌ－２基因蛋白表达阳性的肺癌，肿块毛刺征及三级支气管受累的出现率明显高于表达阴性者（Ｐ＜００５）；当两种基因蛋白在肺鳞癌中共表达时，肿块毛刺征及肺门或纵隔淋巴结转移的出现率明显高于它们单独表达者（Ｐ＜００５）。结论：ｃ－ｅｒｂＢ－２及ｂｃｌ－２基因蛋白与反映肺癌侵袭力的某些影像征象之间可能存在密切的关系。
Purpose and methods: Using immunohistochemical technique LSAB method and computer image analysis system to determine c-erbB-2 and bcl-2 gene protein in 37 cases of lung squamous cell carcinoma and 48 cases of lung adenocarcinoma confirmed by pathology Expression levels, analysis of their expression or co-expression and imaging signs reflecting the invasiveness of lung cancer. RESULTS: The positive expression and localization of c-erbB-2 and bcl-2 proteins in two different types of lung cancer tissues were significantly different. Furthermore, the positive expression of c-erbB-2 protein was positive in lung cancer. The occurrence rate was significantly higher than those with negative expression; the incidence of lung cancer with bcl-2 gene protein expression was significantly higher than that of negative expression in patients with tumor burr sign and tertiary bronchial involvement (P<005); when the two gene proteins were When co-expressed in squamous cell carcinoma of the lung, the incidence of lump burr sign and hilar or mediastinal lymph node metastasis was significantly higher than those expressed separately (P < 0.05). Conclusion: There may be a close relationship between c-erbB-2 and bcl-2 gene proteins and some imaging signs that reflect the invasiveness of lung cancer.