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已知肾内纤维蛋白沉积在抗-GBM肾炎和弥漫性血管内凝血所致的肾功能衰竭中起重要作用。人类肾小球纤维蛋白沉积多见于肾皮质坏死、溶血性尿毒综合症、毛细血管外肾炎和肾移植超急性排异反应。肾小球血管内或球囊腔纤维蛋白沉积的持续存在,可能由于局部细胞纤维蛋白溶解作用的减退所致。为解释这些发现并研究纤维蛋白溶解障碍,作者应用免疫荧光技术对血管性肾病和毛细血管外肾炎患者的肾活检标本进行了研究。方法与结果28例各种肾病患者,男18例,女10例,年龄5～78岁。肾组织标本除4例正常标本中的3例外,均来自经皮针吸肾活检;3例中1例来自肾癌肾切除的肾脏标本;另2例为因血管或泌尿原因而不宜行
Intrarenal fibrin deposition is known to play an important role in renal failure due to anti-GBM nephritis and disseminated intravascular coagulation. Human glomerular fibrin deposition more common in renal cortical necrosis, hemolytic uremic syndrome, extracapillary nephritis and renal transplantation hyperacute rejection. The persistence of fibrin deposition in the glomerular vessels or in the balloon lumen may be due to a decrease in local cellular fibrinolysis. To explain these findings and to study fibrinolytic disorders, the authors used immunofluorescence to study renal biopsy specimens of patients with vascular nephropathy and extra-capillary glomerulonephritis. Methods and Results 28 cases of various kidney disease patients, 18 males and 10 females, aged 5 to 78 years. Kidney tissue samples were obtained from percutaneous needle aspiration biopsy except 3 of the 4 normal specimens, 1 of 3 renal specimens from renal cell nephrectomy, and 2 were not suitable for vascular or urological reasons