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目的：检测骨肉瘤血管内皮细胞中人白细胞 Ｄ Ｒ 抗原（ Ｈ Ｌ Ａ Ｄ Ｒ）和第Ⅷ因子相关抗原（ ＦⅧ Ｒ Ａｇ）的表达，及其对骨肉瘤生物学行为的影响。方法：应用 Ｈ Ｌ Ａ Ｄ Ｒ和 ＦⅧ Ｒ Ａｇ 单克隆抗体对８０ 例骨肉瘤进行免疫组织化学染色。结果：骨肉瘤血管内皮细胞几乎不表达 Ｈ Ｌ Ａ Ｄ Ｒ，而 ＦⅧ Ｒ Ａｇ 呈高表达。结论：骨肉瘤血管内皮细胞主要表现为凝血功能而几乎丧失免疫功能，其与骨肉瘤的转移和预后有密切关系。
Objective: To detect the expression of human leukocyte D R antigen (H L A D R) and factor VIII related antigen (FVIII R Ag) in osteosarcoma vascular endothelial cells and their effects on the biological behavior of osteosarcoma. METHODS: Immunohistochemical staining of 80 cases of osteosarcoma was performed with HL A D R and FVIII R Ag monoclonal antibodies. Results: The vascular endothelial cells of osteosarcoma almost did not express H L A D R, but FVIII R Ag was highly expressed. Conclusion: The vascular endothelial cells of osteosarcoma mainly show coagulation function and almost lose immune function, which is closely related to the metastasis and prognosis of osteosarcoma.