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目的 探讨树突状细胞（ Ｄ Ｃ） 、 Ｔ、 Ｂ 淋巴细胞和浆细胞等免疫活性细胞在 Ｇｒａｖｅｓ 病（ Ｇ Ｄ） 和桥本甲状腺炎（ Ｈ Ｔ） 发病中的作用。方法 用组织化学、免疫组织化学，电镜等方法观察１０５ 例有明显淋巴细胞浸润的 Ｇ Ｄ 和１０４ 例 Ｈ Ｔ 甲状腺实质和间质中免疫活性细胞的形态学变化。并用形态计量学方法，将 Ｇ Ｄ 和 Ｈ Ｔ 按不同浸润程度分组。结果 Ｇ Ｄ Ｉ型：＜ １０ ％ ； Ｇ Ｄ Ｉ Ｉ型：１０ ～２０ ％ ； Ｇ Ｄ Ｉ Ｉ Ｉ型：２０ ～４０ ％ ； Ｈ Ｔ 的 Ｌ 型：２０ ～４０ ％ ； Ｏ 型：４０ ～８０ ％ ； Ｐ 型：８０ ～１００ ％ ，显示 Ｇ Ｄ 和 Ｈ Ｔ 在浸润程度上构成一个连续的谱系，而且 Ｇ Ｄ Ｉ Ｉ Ｉ型和 Ｈ Ｔ 的 Ｌ 型表现出相近似的浸润程度。甲状腺滤泡上皮在 Ｇ Ｄ 以增生状态为主，萎缩、嗜酸性变和退变等变化轻微，在 Ｈ Ｔ 滤泡上皮的增生较少，而萎缩、嗜酸性变和退变等变化逐渐加重，这些变化与 Ｇ Ｄ 发病多以 Ｔ Ｓ Ｉ兴奋 Ｔ Ｓ Ｈ 受体引起功能亢进为主，而 Ｈ Ｔ 以多种自身抗体所引起的免疫损伤作用为主的发病机理相一致。结论 Ｄ Ｃ 和免疫活性细胞在 Ａ Ｉ Ｔ Ｄ 的抗原递呈、进而启动和调节体液、细胞免疫过程中起到至关重要的作?
Objective To investigate the role of immunocompetent cells such as dendritic cells (DCs), T, B lymphocytes and plasma cells in the pathogenesis of Graves’ disease (G D) and Hashimoto’s thyroiditis (H T). Methods The morphological changes of 105 immunocompetent cells in the G D and 104 cases of H T thyroid gland and stroma were observed by histochemistry, immunohistochemistry and electron microscopy. And using morphometry method, G D and H T grouped according to the degree of infiltration. Results Type G D I: <10%; Type G D I I: 10-20%; Type G D I I I: 20-40%; Type L H T: 20-40%; Type O: 40-80 %; Type P: 80-100%, showing that G D and H T form a continuous lineage on the degree of infiltration, and the L-forms of G D I I I and H T show similar degrees of infiltration. Thyroid follicular epithelium mainly proliferated in G D, slightly changed such as atrophic, eosinophilic and degeneration. The hyperplasia of H follicular epithelium was less and the changes of atrophic, eosinophilic and degeneration increased gradually, These changes are mainly associated with the increased incidence of G D and the hypersensitivity induced by T S I-stimulated T S H receptors, whereas H T is consistent with the pathogenesis of immune damage induced by various autoantibodies. Conclusions D C and immunocompetent cells play an important role in initiating and regulating humoral and cellular immune responses by presenting antigen in A T D.