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目的:分析鸦胆子油乳、艾迪注射液配合GP化疗治疗非小细胞肺癌的疗效及对免疫功能的影响。方法:以2010年1月至2016年3月宝鸡市解放军第三医院收治的非小细胞肺癌患者80例为研究对象,根据住院病历号顺序分为观察组和对照组,每组40例,对照组接受GP化疗方案,观察组接受GP化疗方案联合鸦胆子油乳、艾迪注射液治疗,两组均10天为一个周期,4个周期为一个疗程,均治疗1个疗程。比较两组的临床疗效、不良反应、T细胞亚群水平及生活质量评分。结果:观察组的总缓解率和疾病控制率分别为62.5%和92.5%,均显著高于对照组(47.5%和75.0%)(P<0.05);治疗后,两组的CD3~+、CD4~+、CD8~+、CD4~+/CD8~+水平均较治疗前显著降低(P<0.05),观察组治疗后的CD3~+、CD4~+、CD8~+水平均明显高于对照组(P<0.05);两组治疗后的KPS评分均较治疗前升高,且观察组的KPS评分显著高于对照组(P<0.05);治疗期间,观察组的恶心呕吐、腹泻、白细胞计数减少、血小板减少、肝功能损害和肾功能损害的发生率均显著低于对照组(P<0.05);半年内,观察组的生存率(87.5%)显著高于对照组的生存率(77.5%)。结论:鸦胆子油乳、艾迪注射液配合GP化疗治疗非小细胞肺癌的疗效显著,不良反应发生率低,提高半年生存率,而且可降低化疗对T细胞亚群水平的影响,并降低患者血清VEGF水平。
Objective: To analyze the curative effect of javanica oil emulsion and Aidi injection combined with GP chemotherapy on non-small cell lung cancer and its influence on immune function. Methods: From January 2010 to March 2016, 80 patients with non-small cell lung cancer admitted to the Third Hospital of PLA of Baoji City were enrolled in this study. According to the inpatient records, they were divided into observation group and control group, 40 cases in each group. Group received GP chemotherapy, the observation group received GP chemotherapy combined with Brucea javanica oil emulsion, Eddie injection treatment, both groups were 10 days for a cycle, 4 cycles for a course of treatment, were treated for a course of treatment. The clinical efficacy, adverse reactions, T cell subsets and quality of life scores were compared between the two groups. Results: The total remission rate and disease control rate in the observation group were 62.5% and 92.5%, respectively, which were significantly higher than those in the control group (47.5% and 75.0%, P <0.05) CD8 ~ +, CD4 ~ + / CD8 ~ + in the observation group were significantly lower than those before treatment (P <0.05). The levels of CD3 +, CD4 +, CD8 + in the observation group were significantly higher than those in the control group (P <0.05). The KPS scores of both groups were higher than those before treatment, and the KPS scores in the observation group were significantly higher than those in the control group (P <0.05). During the treatment period, the observation group had nausea and vomiting, diarrhea, white blood cell count (P <0.05). The survival rate of the observation group (87.5%) was significantly higher than that of the control group (77.5%) in the first half of the year, but the incidence of thrombocytopenia, liver damage and renal dysfunction were significantly lower than those in the control group ). Conclusion: Brucea javanica oil and Aidi injection combined with GP chemotherapy in the treatment of non-small cell lung cancer have significant curative effect, low incidence of adverse reactions, increased half-year survival rate, and can reduce the impact of chemotherapy on T cell subsets and reduce the patients Serum VEGF levels.