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目的:评价术中不同吸入氧浓度(FiOn 2)对腹腔镜手术老年患者术后谵妄(POD)的影响。n 方法:选择2018年2月至2020年2月择期静吸复合全麻下腹腔镜手术老年患者700例，年龄65～85岁，体重50～80 kg，ASA分级Ⅰ或Ⅱ级。采用随机数字表法分为2组(n n＝350)：FiOn 240%(A组)和FiOn 280%(B组)。术中采用不同FiOn 2以容量控制模式行机械通气，于诱导前(Tn 1)、手术45 min(Tn 2)、手术90 min(Tn 3)和手术结束前10 min(Tn 4)时记录脑氧饱和度(rSOn 2)和动脉血气分析指标。于入PACU至术后7 d内，记录肺不张和POD发生情况。n 结果:最终纳入患者664例，A组333例，B组331例。与B组比较，A组Tn 2～4时rSOn 2和PaOn 2降低，肺不张发生率降低(n P0.05)。n 结论:术中FiOn 240%和80%对腹腔镜手术老年患者POD发生无明显影响，然而FiOn 240%有助于降低术后肺不张的发生。n “,”Objective:To evaluate the effect of different intraoperative inhaled oxygen concentrations (FiOn 2) during surgery on postoperative delirium (POD) in elderly patients undergoing laparoscopic surgery.n Method:A total of 700 patients, aged 65-85 yr, weighing 50-80 kg, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, underwent laparoscopic surgery under general anesthesia from February 2018 to February 2020, were selected.The patients were randomly divided into 2 groups (n n=350 each) using a random number table method: 40% FiOn 2 group (group A) and 80% FiOn 2 group (group B). Mechanical ventilation was performed with different FiOn 2 in volume-controlled mode.Cerebral oxygen saturation (rSOn 2) and arterial blood gas analysis were recorded before induction (Tn 1) and at 45 min of operation (Tn 2), 90 min of operation (Tn 3) and 10 min before the end of operation (Tn 4). The development of atelectasis and POD were recorded from the day on admission to PACU to 7 days after operation.n Results:Six hundred and sixty-four patients were finally enrolled, including 333 cases in group A and 331 cases in group B. Compared with group B, rSOn 2 and PaOn 2 were significantly decreased at Tn 2-4, and the incidence of atelectasis was decreased (n P0.05).n Conclusion:Intraoperative 40% and 80% FiOn 2 has no significant effect on the development of POD in elderly patients undergoing laparoscopic surgery, however, 40% FiOn 2 is helpful in reducing the occurrence of postoperative atelectasis.n