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多种动物研究表明分娩时子宫前列腺索(PG)产生增加。有研究表明雌二醇(E_2) 和孕酮(P)有助于调节子宫 PG 的产生。实验研究用 SD(SpragueDawley)大鼠,将离体子宫组织置于含有 P 或 E_2(0. 1,1,10,100和1000ng/ml)的 Ham 氏 F-10,37℃培养液中孵育48小时,然后直接分析培养液中 PGE、PGF 以及用放免法测定培养液中P 含量。实验分四组。第一组研究妊娠19天和21天的子宫,观察增加 P 和 E_2浓度时,PG 产生和剂量依赖方式。
Various animal studies have shown an increased production of uterine prostate gland (PG) during labor. Studies have shown that estradiol (E2) and progesterone (P) help regulate uterine PG production. EXPERIMENTAL STUDY Ex vivo uterine tissue was incubated in Ham’s F-10, 37 ° C medium containing P or E 2 (0.1, 1, 100, and 1000 ng / ml) for 48 hours in SD rats, Then directly analyze the PGE, PGF in culture medium and determine the content of P in culture medium by radioimmunoassay. The experiment is divided into four groups. The first group studied the uterus on days 19 and 21 of gestation and observed PG production and dose-dependent patterns of increased P and E 2 concentrations.