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目的为了探讨食管癌组织ｃ－ｅｒｂＢ－２的表达及其临床意义。方法采用ＳＰ免疫组织化学法对４１例食管癌标本进行ｃ－ｅｒｂＢ－２的检测。结果４１例食管癌中，ｃ－ｅｒｂＢ－２阳性表达率为５１．２％（２１／４１），其中高分化组ｃ－ｅｒｂＢ－２阳性率为３３．３％，中分化组为４２．１％，低分化组为７６．９％，低分化组和高分化组相比较，两组间有显著性差异（Ｐ＜０．０５）。在有淋巴结转移的食管癌中，ｃ－ｅｒｂＢ－２癌基因表达率为６５．５％（１９／２９），而无淋巴结转移者中的ｃ－ｅｒｂＢ－２癌基因阳性表达率为１６．７％（２／１２），二者相比有非常显著性差异（Ｐ＜０．０１）。１０例正常食管粘膜中ｃ－ｅｒｂＢ－２癌基因则均为阴性。结论ｃ－ｅｒｂＢ－２癌基因不仅是食管癌的一种新的标志物，而且还与食管癌的分化程度、淋巴结的转移有关，ｃ－ｅｒｂＢ－２的检测可成为食管癌诊断和判定预后有价值的指标。
Objective To investigate the expression of c-erbB-2 in esophageal carcinoma and its clinical significance. Methods SP immunohistochemistry was used to detect c-erbB-2 in 41 specimens of esophageal cancer. Results The positive expression rate of c-erbB-2 in 41 cases of esophageal cancer was 51.2% (21/41). The positive rate of c-erbB-2 was 33.3% in highly differentiated group and 42.1 in moderately differentiated group. %, 76.9% in the poorly differentiated group, compared with the poorly differentiated group and the highly differentiated group, there was a significant difference between the two groups (P<0.05). In esophageal cancer with lymph node metastasis, the c-erbB-2 oncogene expression rate was 65.5% (19/29), whereas the c-erbB-2 oncogene positive expression rate was 16.7 in patients without lymph node metastasis. % (2/12), there was a very significant difference between the two (P<0.01). The c-erbB-2 oncogene was negative in 10 normal esophageal mucosa. Conclusion The c-erbB-2 oncogene is not only a new marker of esophageal cancer, but also related to the degree of differentiation of esophageal cancer and the metastasis of lymph nodes. The detection of c-erbB-2 can be used to diagnose and determine the prognosis of esophageal cancer. The index of value.