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目的观察慢性肾脏病(CKD)患者血清甲状腺激素(TH)的变化。方法选择50例CKD患者作为观察组(CKD组),50例同期进行体检的健康人作对照组,测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)浓度及肾功能。结果 CKD组FT3(1.76±0.23)pmol/L、FT4(7.26±1.38)pmol/L,明显低于对照组的(5.42±0.56)pmol/L、FT4(16.54±3.73)pmol/L(P<0.05)。CKD组FT3、FT4分别与血尿素氮、肌酐呈负相关(P<0.01)。结论动态监测CKD患者血清TH的变化,对于判断患者的病情轻重与预后具有重要的参考价值。
Objective To observe the changes of serum thyroid hormone (TH) in patients with chronic kidney disease (CKD). Methods Fifty patients with CKD were selected as the observation group (CKD group) and 50 healthy people as the control group. The levels of serum free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin TSH) concentration and renal function. Results FT3 was significantly lower in CKD group than in control group (1.76 ± 0.23 pmol / L and FT4 7.26 ± 1.38 pmol / L, 5.42 ± 0.56 pmol / L and FT4 16.54 ± 3.73 pmol / L, P < 0.05). FT3 and FT4 in CKD group were negatively correlated with blood urea nitrogen and creatinine (P <0.01). Conclusion Dynamic monitoring of serum CKD patients with changes in the TH for determining the severity of the patient’s condition and prognosis of an important reference value.