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Objective:To observe the clinical therapeutic effect on migraine treated with acupuncture combined with blood-letting therapy.rnMethods:A total of 90 patients of migraine were included in compliance with the requirement and di-vided into a blood-letting therapy group,a western medication group,an acupuncture plus blood-letting therapy group,30 cases in each one according to the random number table.In the two control groups,the simple blood-letting therapy was exerted at Dàzhuī(大椎GV14)and the oral administration with carba-mazepine were provided respectively.In the acupuncture plus blood-letting therapy group,acupuncture was exerted at Bǎihuì(百会 GV20)and other points,with blood-letting therapy combined.The treatment was given once daily and 12 treatments were as one course.After 2 courses of treatment,the score of therapeutic effect on symptoms and signs,pain score of visual analogue scale(VAS)and clinical therapeu-tic effect were compared among the three groups before and after treatment.rnResults:At the end of treatment,the scores for symptoms and signs and VAS score were reduced ob-viously as compared with those before treatment in the three groups(all P ＜ 0.01).Compared with the blood-letting therapy group and the medication group,the scores for symptoms and signs and VAS score were all reduced more obviously in the acupuncture plus blood-letting therapy group respectively(all P＜ 0.01)and the differences were not significant between the blood-letting therapy group and the medi-cation group(P ＞ 0.05).The total effective rate in the acupuncture plus blood-letting therapy group was higher obviously than either the blood-letting therapy group or the medication group(both P ＜ 0.05).rnConclusion:Acupuncture combined with blood-letting therapy achieves a better clinical therapeutic ef-fect on migraine as compared with either simple blood-letting therapy or medication.Such combined treatment obtains a satisfactory therapeutic results and deserves to be promoted in clinical application.