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目的 :研究核转录因子κB(NP -κB)和表皮生长因子受体 (EGFR)在细支气管肺泡癌 (BAC)的表达及意义。方法 :应用S -P免疫组织化学染色方法检测 2 1例手术切除BAC中NF -κBp6 5及EGFR的表达。结果 :2 1例BAC中NF -κBp6 5和EGFR阳性率分别为 71.4 %和 76 .2 % ,而且其表达强度明显高于癌旁支气管上皮细胞和肺泡上皮细胞 ;NF -κBp6 5和EGFR在BAC中的表达强度呈明显正相关 ,但与BAC的组织学分型及淋巴结转移均无明显关系。结论 :BAC中NF -κB和EGFR的过度表达可能参与了其发生发展过程
Objective: To study the expression and significance of nuclear factor kappa B (NF-κB) and epidermal growth factor receptor (EGFR) in bronchial alveolar carcinoma (BAC). Methods: S-P immunohistochemical staining was used to detect the expression of NF-κBp65 and EGFR in 21 cases of BAC. Results: The positive rate of NF-κBp65 and EGFR in 71 BACs was 71.4% and 76.2% respectively in 21 BACs, and the expression of NF-κBp65 and EGFR in BAC was significantly higher than that in paracancerous bronchial epithelial cells and alveolar epithelial cells. In the expression intensity was positively correlated, but with histological type and lymph node metastasis BAC no significant relationship. Conclusion: The overexpression of NF-κB and EGFR in BAC may be involved in the process of their development