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1例17个月男性患儿,因1型糖尿病行自体造血干细胞移植入院。入院后皮下注射非格司亭5.0μg/kg行造血干细胞动员,给予环孢素25mg,2次/d口服,第12天肝功能正常。停用环孢素,改用抗胸腺细胞球蛋白(ATG)静脉滴注。第1天应用ATG8mg,第2天应用12mg,随后血生化检查:ALT1041U/L,AST209.3U/L,ALP296.4U/L,LDH695.1U/L,TBil19.3μmol/L,DBil11.7μmol/L。立即停用ATG,给予保肝治疗,肝功能逐渐好转。20d后行造血干细胞回输,无不适出院。随访半年肝功能正常。
A case of 17-month-old male with autologous hematopoietic stem cell transplantation for type 1 diabetes admitted to hospital. After admission, subcutaneous injection of filgrastim 5.0μg / kg hematopoietic stem cell mobilization, given cyclosporine 25mg, 2 times / d orally, the first 12 days of normal liver function. Disable cyclosporine, switch to anti-thymocyte globulin (ATG) intravenous infusion. ATG 8 mg on day 1 and 12 mg on day 2 followed by blood biochemical tests: ALT1041U / L, AST209.3U / L, ALP296.4U / L, LDH695.1U / L, TBil19.3μmol / L, DBil11.7μmol / L . ATG stop immediately, give liver protection, liver function gradually improved. After 20d hematopoietic stem cell transfusion, no discomfort discharged. Six months follow-up normal liver function.