对实体瘤的染色体分析常发现有很复杂的畸变,以致难以从非特异性(继发的)变化中区分出特异性(原发的)变化。因此,为了提高发现特异性染色体变化的可能性,需要进一步研究良好显带的中期分裂相。在恶性黑色素瘤(MM)中常发现第1号染色体畸变,可是,据报导在其它肿瘤中也有这种畸变,因此,至今不能根据这种畸变来识别肿瘤器官的特异性。最近在作者的实验中发现第6号染色体在恶性黑色素瘤中起重要作用的证据。在作者研究的三个病例中,经短期培养后发 Chromosomal analysis of solid tumors often finds complex aberrations that make it difficult to distinguish specific (primary) changes from non-specific (secondary) changes. Therefore, in order to improve the possibility of finding specific chromosome changes, it is necessary to further study the well-significant metaphase. Malignant melanoma (MM) often finds chromosome 1 aberrations, but it has also been reported in other tumors. Therefore, the specificity of tumor organs cannot be identified based on such distortion. In the author’s experiment recently, it was found that chromosome 6 plays an important role in malignant melanoma. In the three cases studied by the author, after short-term training