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Burkitt淋巴瘤(即非洲儿童淋巴瘤,缩写为BL)是赤道非洲和新几内亚的一种较常见地方病,其他各洲偶可见到散发型病例。本病首先由Burkitt(1959)首先报告,主要发生于童年,其平均初发年龄:地方型者7岁,散发型者11岁,罕见于2岁以前。最好发部位为:腹腔、腹膜后、面骨、甲状腺、涎腺、骨髓及中枢神经系统,罕发于淋巴系统(尤以咽淋巴环受累者为少)。BL和鼻咽癌在人类恶性肿瘤中具有特殊地位,二者均可能系由EB病毒所诱发,几乎全部地方型BL患者的瘤细胞内均有EB病毒的染色体组(genome),而散发型患者中仅8～17%有上述发现。BL的增生非常活跃,治疗靠各种联
Burkitt lymphoma (namely, African childhood lymphoma, abbreviated as BL) is a more common endemic disease in equatorial Africa and New Guinea, with sporadic cases occasionally seen in other continents. The disease was first reported by Burkitt (1959). It mainly occurred in childhood. Its average age of onset was: 7 years old for local type, 11 years old for sporadic type, and rarely before 2 years old. The best hair sites are: abdominal cavity, retroperitoneum, facial bone, thyroid gland, parotid gland, bone marrow, and central nervous system, and rarely in the lymphatic system (especially those with pharyngeal lymphatic ring involvement are few). BL and nasopharyngeal carcinoma have a special status in human malignancies, both of which may be induced by Epstein-Barr virus. Almost all localized BL patients have genomic Epstein-Barr virus (genome) in tumor cells and sporadic patients. Only 8 to 17% of the above findings were found. The hyperplasia of BL is very active.