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目的研究急性有机磷农药中毒(AOPP)患者血清胆碱酯酶(ChE)、淀粉酶(AMS)、肌酸激酶同工酶(CK-MB)及空腹血糖(FBS)水平的变化及其临床意义。方法选取160例AOPP患者,根据中毒的程度分为轻度、中度、重度3组,健康体检者为对照组,分别抽静脉血3ml检测ChE、AMS、CK-MB及FBS。结果中毒组血清AMS、CK-MB及FBS水平均显著高于对照组(P<0.05),ChE水平显著低于对照组(P<0.05)。随患者中毒程度轻→中→重度的递增,其AMS、CK-MB及FBS水平递升(P<0.05),且不同程度间两两比较差异有统计学意义(P均<0.05);ChE下降水平不能反映中毒程度,差异无统计学意义(P>0.05)。结论检测AOPP患者血清ChE、AMS、CK-MB及FBS水平,对诊断AOPP、判断病情严重程度、指导治疗有重要的临床意义。
Objective To study the changes of serum ChE, AMS, CK-MB and FBS in patients with acute organophosphorus pesticide poisoning (AOPP) and its clinical significance . Methods 160 patients with AOPP were divided into mild, moderate and severe groups according to the degree of poisoning. The healthy subjects were taken as the control group, and 3 ml of venous blood was taken respectively to detect ChE, AMS, CK-MB and FBS. Results Serum levels of AMS, CK-MB and FBS in the poisoning group were significantly higher than those in the control group (P <0.05), while the level of ChE in the poisoning group was significantly lower than that in the control group (P <0.05). The levels of AMS, CK-MB and FBS increased with the mild → moderate → severe increase (P <0.05), and there was a significant difference between the two groups in any degree (P <0.05) Can not reflect the degree of poisoning, the difference was not statistically significant (P> 0.05). Conclusion Detecting serum levels of ChE, AMS, CK-MB and FBS in AOPP patients has important clinical significance in diagnosing AOPP, judging the severity of the disease and guiding the treatment.